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KMID : 0978920100110020154
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Korean Journal of Clinical Geriatrics
2010 Volume.11 No. 2 p.154 ~ p.169
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The Relationship between Vitamin D Levels and Chronic Diseases
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Chung Yoo-Seok
Yoo Byung-Wook
Oh Jung-Eun
Lee Duk-Chul
Lee Hong-Soo
Cho Choo-Yon
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Abstract
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Background: Vitamin D deficiency is prevalent worldwide, not only in patients with osteoporosis but also in normal adults. Because the situation is especially severe in Korea. So, we take a look at the degree
of vitamin D deficiency in Korea and the relationship between chronic diseases which are common in primary care and vitamin D level.
Methods: 200 patients above the age of 20, who were admitted to the Department of Family Medicine at Soonchunhyang University from June of 2009 to May of 2010 were chosen. Questionnaires regarding
the patients’ drug history and afflicted disease and the average serum 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D levels were obtained and we looked into their relationships to the diagnosed chronic disease or possessed chronic disease such as like diabetes, hypertension, osteoporosis, hyperlipidemia.
Results: In our study a serum 25(OH)D level lower than 80 nmol/dL (32 ng/mL) was considered vit D deficient.
127 patients (63.5%) were deficient in vit D and 126 patients (73%) were beyond adequacy. The serum 25(OH)D showed a significant positive relationship with total cholesterol (P=0.01), triglyceride (P=0.049), High
density lipoprotein-cholesterol (P=0.001), and Low density lipoprotein-cholesterol (P=0.007). The serum 1,25 (OH)2D3 showed a significant negative relationship with Triglyceride (0.018). The serum 25(OH)D level was not shown any significant effect by Fasting plasma glucose, HbA1c, Total cholesterol, Triglyceride, High density lipoprotein, Low density lipoprotein. The serum 25(OH)D showed no significant relationship with the presence of existing diseases as diabetes, hypertension, hyperlipidemia, osteoporosis or newly diagnosed as same above at admitted. also, the serum 1,25 (OH)2D3 showed a significant negative relationship with the presence of existing diseases as diabetes, hypertension, hyperlipidemia, osteoporosis or newly diagnosed
as same above at admitted. Preexisting treatment history or newly diagnosed at admission of diabetes (P=0.003) and hypertension (P=0.009) showed a significant inversely proportional correlation to the serum
1,25 (OH)2D3 level and of hyperlipidemia showed a significant directly proportional relationship to the serum 1,25 (OH)2D3 level (P=0.008).
Conclusion: About a two-thirds of those surveyed is found to have vitamin D deficiency. Vitamin D, in addition to its role in bone metabolism, seems to have an effect on the genesis of hypertension and diabetes.
So, it is considered that a further prospective study on the clinical usefulness of vitamin D will be needed for chronic diseases increases due to the increase of the elderly population.
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KEYWORD
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Vitamin D Level, Chronic Disease
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